4th International Neonatal
& Maternal Immunization Symposium
Towards Integrating Maternal and Infant Immunization Programs
September 10-12, 2017 - Brussels (Belgium)

Scientific program

Sunday September 10th
12:00 - 13:30 Lunch
13:30 - 13:45 Welcome • Arnaud Marchant, Pierre Van Damme
13:45 - 14:15 Opening lecture
13:45 - 14:15 The integration of infant and maternal immunization: A global challenge!
Philipp Lambach
Initiative for Vaccine Research
World Health Organization, Switzerland
14:15 - 15:50 Antibodies and their transfer • Chair: Arnaud Marchant, Ofer Levy
14:15 - 14:40 Helping vaccine design with systems serology
Margaret Ackerman
Dartmouth College, USA
14:40 - 15:05 Placental biology and transfer of maternal immunity
Dana Wolf
Hadassah University Hospital, Israel
15:05 - 15:20 Mathematical modelling of maternal antibodies: the quest for the kinetics
Thao Mai Phuong Tran • University of Hasselt, Belgium
15:20 - 15:35 Breast milk lymphocyte response to prenatal vaccination with Pneumococcal Conjugate Vaccine-13
Mustapha Jaiteh • Medical Research Council Unit, The Gambia
15:35 - 15:50 Open discussion
15:50 - 16:10 Coffee break
16:10 - 18:30 Neonatal immunization • Chair: Ener Dinleyici, Arnaud Marchant
16:10 - 16:35 Immune response to vaccines in early life
Beate Kampmann
Imperial College London, United Kingdom
16:35 - 16:50 Prevalence and decay of maternal pneumococcal and meningococcal antibodies in 8022 infants: a meta-analysis of type-specific decay rates
Merryn Voysey • University of Oxford, United Kingdom
16:50 - 17:05 Licensed Bacille Calmette Guérin (BCG) vaccine formulations demonstrate markedly different content of live mycobacteria and distinct age-dependent innate cytokine induction in human blood in vitro
Ofer Levy • Harvard Medical School, USA
17:05 - 17:30 Neonatal immunization against bacterial pathogens
Nicholas Wood
University of Sydney, Australia
17:30 - 17:45 Maternal or neonatal vaccination with Prevenar13 on infant pneumo specific memory B cell response in the Gambia
Amadou Faal • Medical Research Council Unit, The Gambia
17:45 - 18:00 Maternal milk enhances intestinal mucosal barrier and immunity in a pediatric human enteroid model
Gaelle Noel • University of Maryland School of Medicine, USA
18:00 - 18:15 Effect of maternally-derived anti-protein and anti-capsular IgG antibodies on the rate of acquisition of nasopharyngeal carriage of pneumococcus in newborns
John Ojal • KEMRI-Wellcome Trust Research Programme, Kenya
18:15 -18:30 Open discussion
20:00 Dinner in town
Monday September 11th
8:30 - 9:40 Heterologous immunity • Chair: Beate Kampmann, Ofer Levy
8:30 - 8:55 Immunological mechanisms of heterologous vaccine effects
Mihai Netea
Radboud Universitair Medisch Centrum, The Netherlands
8:55 - 9:10 STING and TLR7/8 activation promotes type 1 immunity for early life immunization
Carlo Pietrasanta • Harvard Medical School, USA
9:10 - 9:25 Impact of maternal and environmental factors, including in utero exposition to HIV and malaria, in the immunological response of infants to vaccines and infections
Selena Alonso • Barcelona Institute for Global Health, Spain
9:25 - 9:40 Open discussion
9:40 - 10:00 Coffee break
10:00 - 11:45 Update on vaccines under development for maternal and neonatal immunization • Chair: Paul Heath, Clare Cutland
10:00 - 10:25 RSV immunization in pregnancy
Fiona Culley
Imperial College London, United Kingdom
10:25 - 10:40 Immunological risk of infection related hospitalization in HIV-exposed uninfected infants
Jishnu Das • Ragon Institute, USA
10:40 - 10:55 GBS immunization in pregnancy
Shabir Madhi
National Institute for Communicable Diseases, RSA
University of the Witwatersrand, RSA
10:55 - 11:10 Prevalence and Capsular Types of Group B Streptococci (GBS) Colonizing Indian women living in the United States (US): relevance to GBS vaccine development
Manu Chaudhary • Baylor College of Medicine, USA
11:10 - 11:25 A novel vaccine against Group B Streptococcal disease is well tolerated and highly immunogenic in a Phase 1 trial
Per Fischer • Minervax ApS, Denmark
11:25 - 11:45 Open discussion
11:45 - 14:00 Posters and lunch
14:00 - 15:30 Update on vaccines under development for maternal and neonatal immunization (cont.) • Chair: Pierre Van Damme, Elke Leuridan
14:00 - 14:25 Pertussis immunization in pregnancy
Kathryn Edwards
Vanderbilt University School of Medicine, USA
14:25 - 14:40 Assessment of IgG antibody to pertussis toxin after Tdap vaccination in Thai pregnant women
Nasamon Wanlapakorn • Chulalongkorn University, Thailand
14:40 - 14:55 Maternal and Infant Immune Responses to Pertussis Vaccination in Pregnancy
Thomas Rice • Imperial College London, United Kingdom
14:55 - 15:10 Tdap vaccination during pregnancy and infant's immune response against Bordetella pertussis vaccine
Carolina Argondizo Correia • Adolfo Lutz Institute, Brazil
15:10 - 15:30 Open discussion
15:30 - 15:55 Safety, awareness and perception of maternal and neonatal immunization • Chair: Ed Clarke, Flor Munoz
15:30 - 15:55 Perception of risk related to maternal and neonatal immunization: The importance of building trust
Heidi Larson
London School of Hygiene and Tropical Medicine, United Kingdom
15:55 - 16:15 Coffee break
16:15 - 18:30 Safety, awareness and perception of maternal and neonatal immunization (cont.) • Chair: Ed Clarke, Flor Munoz
16:15 - 16:40 Assessment of safety - Harmonization efforts
Linda Eckert
University of Washington, USA
16:40 - 17:05 Perspective: Assessment of safety and efficacy of maternal vaccines in LMIC
Clare Cutland
University of the Witwatersrand, RSA
17:05 - 17:20 No association between influenza vaccination during pregnancy and adverse birth outcomes
Ousseny Zerbo • Kaiser Permanente Vaccine Study Center, USA
17:20 - 17:35 Understanding maternal and neonatal vaccination acceptance in The Gambia
Penda Johm • Medical Research Council Unit, The Gambia
17:35 - 17:50 Developing capabilities to monitor the safety of vaccine use during pregnancy in Sentinel's PRISM Program
Steve Anderson • US Food and Drug Administration, USA
17:50 - 18:15 Open discussion
19:30 Concert and dinner at Brussels Town Hall
Tuesday September 12th
8:30 - 10:20 Implementing maternal and neonatal immunization worldwide • Chair: Pierre Van Damme, Ed Clarke
8:30 - 8:55 Global perspectives on the implementation of maternal immunization programmes – Opportunities and challenges
Philipp Lambach
World Health Organization, Switzerland
8:55 - 9:20 Integrating maternal and young infant immunization schedules
Edwin Asturias
University of Colorado Denver, USA
Children's Hospital Colorado, USA
9:20 - 9:35 Vaccination against pertussis should be given early in pregnancy to benefit both terms and perterm neonates
Begoña Martinez de Tejada • University Hospitals of Geneva, Switzerland
9:35 - 9:50 An update on the successes and challenges of maternal pertussis immunisation in England
Gayatri Amirthalingam • Public Health England, UK
9:50 - 9:55 Maternal Immunization Clinical Research in Low- and Middle-Income Countries: Study Design, Regulatory and Safety Considerations
Sonali Kochhar • Global Healthcare Consulting, India
9:55 - 10:00 Introducing IMPRINT: IMmunising PRegnant women and INfants neTwork
Beate Kampman • Medical Research Council Unit, The Gambia
10:00 - 10:20 Open discussion
10:20 - 10:40 Coffee break
10:40 - 12:00 PANEL DISCUSSION: Implementing and integrating maternal and infant immunization: Challenges and opportunities • Chair: Flor Munoz
Participants: Azhar Abid Raza, UNICEF • Edwin Asturias, University of Colorado Denver • Nele Berthels, FAMHP Belgium • Ed Clarke, MRC Unit, The Gambia • Claire Cutland, University of the Witwatersrand • Linda Eckert, University of Washington • Philipp Lambach, World Health Organization • Elke Leuridan, University of Antwerp
12:00 - 14:00 Poster and lunch
14:00 - 15:30 New and future targets of maternal and neonatal immunization • Chair: Paul Heath, Ener Dinleyici
14:00 - 14:25 New and future targets of maternal and neonatal immunization
James Crowe
Vanderbilt University Medical Center, USA
14:25 - 14:40 Safety and immunogenicity of ChAd63/MVA ME-TRAP malaria vectored vaccine given with routine EPI vaccines in Gambian infants and neonates: a randomised controlled trial
Sophie Roetynck • Medical Research Council Unit, The Gambia
14:40 - 14:55 Naturally-acquired and vaccine-induced maternal immunity for protection of young infants against shigellosis
Esther Ndungo • University of Maryland School of Medicine, USA
14:55 - 15:10 Vaccines addressing antimicrobial resistance: potential role of maternal immunization?
Ajoke Sobanjo-ter Meulen • Gates Foundation, USA
15:10 - 15:30 Open discussion
15:30 - 16:30 PANEL DISCUSSION: Key messages from stakeholders • Chair: Beate Kampmann
Participants: Mutapha Bittaye, MRC Unit The Gambia • Sonali Kochhar, Global Healthcare Consulting • Kirsty LeDoare, Imperial College London • Pieter Neels, Vaccine-Advice BVBA • Martin Ota, WHO Africa Regional Office • Ajoke Sobanjo ter-Meulen, Gates Foundation • Ivo Vojtek, GSK Vaccines
16:30 - 16:45 Final comments
Pierre Van Damme
Universiteit Antwerpen, Belgium
Arnaud Marchant
Université Libre de Bruxelles, Belgium
16:45 Meeting adjourns